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Daily Archives: 2026年6月19日
Good questions
- Validation of Mutant-Specific Effects The additional methodological details on mutant construction and genome validation are appreciated. However, the study still lacks functional complementation or equivalent validation to demonstrate that the observed phenotypes are directly attributable to loss of the targeted efflux pumps rather than secondary regulatory consequences. Reliance on knockout mutants alone limits confidence in causal interpretation, particularly for broad transcriptomic and stress-response phenotypes. 突变体特异性效应的验证 感谢作者补充了关于突变体构建和基因组验证的额外方法学细节。然而，本研究仍缺乏功能回补或等效的验证手段，来证明所观察到的表型是直接由靶向外排泵的缺失引起的，而非继发性的调控后果。仅依赖敲除突变体限制了因果推断的可靠性，尤其是对于广泛的转录组与应激反应表型而言。